Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow

The aim of the present study was to assess the role of endothelin (ET) in ischemia-reperfusion (I/R)-induced mucosal injury. Mucosal permeability (51Cr-EDTA clearance) and tissue myeloperoxidase (MPO) activity were significantly increased after 30 min of ischemia followed by 30 min of reperfusion. T...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2002-04, Vol.45 (4), p.G647-G655
Main Authors: OKTAR, Berna K, GÜLPINAR, M. Ali, BOZKURT, Ayhan, GHANDOUR, Salah, CETINEL, Sule, MOINI, Hadi, YEGEN, Berrak C, BILSEL, Serpil, GRANGER, D. Neil, KURTEL, Hizir
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels
Enzymes
Excretory system
Gastroenterology. Liver. Pancreas. Abdomen
Medical sciences
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:The aim of the present study was to assess the role of endothelin (ET) in ischemia-reperfusion (I/R)-induced mucosal injury. Mucosal permeability (51Cr-EDTA clearance) and tissue myeloperoxidase (MPO) activity were significantly increased after 30 min of ischemia followed by 30 min of reperfusion. The I/R-induced increases in mucosal permeability and polymorphonuclear leukocyte (PMN) infiltration were significantly attenuated by pretreatments with ETA (BQ-485) and/or ETB (BQ-788.) receptor antagonists.
ISSN:0193-1857
1522-1547