Accessibility of glycolipid and oligosaccharide epitopes on rabbit villus and follicle-associated epithelium

The initial step in many mucosal infections is pathogen attachment to glycoconjugates on the apical surfaces of intestinal epithelial cells. We examined the ability of virus-sized (120-nm) and bacterium-sized (1-mum) particles to adhere to specific glycolipids and protein-linked oligosaccharides on...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2000-06, Vol.41 (6), p.G915-G923
Main Authors: MANTIS, N. J, FREY, A, NEUTRA, M. R
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cells
Fundamental and applied biological sciences. Psychology
Infections
Intestine. Mesentery
Rabbits
Stomach
Vertebrates: digestive system
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Summary:The initial step in many mucosal infections is pathogen attachment to glycoconjugates on the apical surfaces of intestinal epithelial cells. We examined the ability of virus-sized (120-nm) and bacterium-sized (1-mum) particles to adhere to specific glycolipids and protein-linked oligosaccharides on the apical surfaces of rabbit Pever's patch villus enterocytes, follicle-associated enterocytes, and M cells.
ISSN:0193-1857
1522-1547