Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events

In understanding mechanisms of liver repopulation with transplanted hepatocytes, we studied the consequences of hepatic polyploidization in the two-thirds partial hepatectomy model of liver regeneration.

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 1999-05, Vol.39 (5), p.G1260-G1272
Main Authors: SIGAL, S. H, RAJVANSHI, P, GORLA, G. R, SOKHI, R. P, SAXENA, R, GEBHARD, D. R, REID, L. M, GUPTA, S
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cells
Liver
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Description
Summary:In understanding mechanisms of liver repopulation with transplanted hepatocytes, we studied the consequences of hepatic polyploidization in the two-thirds partial hepatectomy model of liver regeneration.
ISSN:0193-1857
1522-1547