Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM

Recent studies show that nonamidated gastrins (Gly-gastrin and progastrin) stimulate colonic proliferation. However, the role of nonamidated vs. amidated gastrins in colon carcinogenesis has not been defined.

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2000-03, Vol.41 (3), p.G390-G399
Main Authors: SINGH, P, VELASCO, M, GIVEN, R, WARGOVICH, M, VARRO, A, WANG, T. C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinogens
Colon
Gastroenterology. Liver. Pancreas. Abdomen
Medical sciences
Rodents
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Description
Summary:Recent studies show that nonamidated gastrins (Gly-gastrin and progastrin) stimulate colonic proliferation. However, the role of nonamidated vs. amidated gastrins in colon carcinogenesis has not been defined.
ISSN:0193-1857
1522-1547