Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo

The aim of this study was to investigate the permeability of the adherent mucus gel layer in rat duodenum in vivo to macromolecules applied in the lumen. Rats were anesthetized with thiobarbiturate, and the duodenum was perfused with isotonic NaCl solution containing large-molecular-size secretagogu...

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Published in:American journal of physiology: Gastrointestinal and liver physiology 1999-08, Vol.40 (2), p.G375
Main Authors: Flemstrom, Gunnar, Hallgren, Anneli, Nylander, Olof, Engstrand, Lars
Format: Article
Language:English
Subjects:
Bacteria
Digestive system
Permeability
Rodents
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container_title American journal of physiology: Gastrointestinal and liver physiology
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creator Flemstrom, Gunnar
Hallgren, Anneli
Nylander, Olof
Engstrand, Lars
description The aim of this study was to investigate the permeability of the adherent mucus gel layer in rat duodenum in vivo to macromolecules applied in the lumen. Rats were anesthetized with thiobarbiturate, and the duodenum was perfused with isotonic NaCl solution containing large-molecular-size secretagogues.
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source American Physiological Society Free
subjects Bacteria
Digestive system
Permeability
Rodents
title Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo
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