Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver

Cell transplantation into hepatic sinusoids could cause hepatic ischemia. To examine the effects of cell transplantation on host hepatocytes, Gupta et al transplanted Fisher 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. Within 24 hours of cell transplantation, areas of i...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2000-10, Vol.42 (4), p.G815-G826
Main Authors: GUPTA, Sanjeev, RAJVANSHI, Pankaj, MALHI, Harmeet, SLEHRIA, Sanjeev, SOKHI, Rana P, VASA, Srinivasa R. G, DABEVA, Mariana, SHAFRITZ, David A, KERR, Andrew
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells
Genes
Injuries
Liver
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Rodents
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Transplants & implants
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Summary:Cell transplantation into hepatic sinusoids could cause hepatic ischemia. To examine the effects of cell transplantation on host hepatocytes, Gupta et al transplanted Fisher 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. Within 24 hours of cell transplantation, areas of ischemic necrosis appeared in the liver.
ISSN:0193-1857
1522-1547