Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide

Gastrointestinal stasis during sepsis may be associated with gastrointestinal smooth muscle dysfunction. Endotoxin {lipopolysaccharide (LPS)} impairs smooth muscle contraction, in part through inducible nitric oxide synthase (NOS II) and enhanced nitric oxide production.

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 1999-06, Vol.39 (6), p.G1356-G1362
Main Authors: LODATO, R. F, KHAN, A. R, ZEMBOWICZ, M. J, WEISBRODT, N. W, PRESSLEY, T. A, LI, Y.-F, LODATO, J. A, ZEMBOWICZ, A, MOODY, F. G
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Digestive system
Experimental bacterial diseases and models
Infectious diseases
Medical sciences
Muscular system
Proteins
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Description
Summary:Gastrointestinal stasis during sepsis may be associated with gastrointestinal smooth muscle dysfunction. Endotoxin {lipopolysaccharide (LPS)} impairs smooth muscle contraction, in part through inducible nitric oxide synthase (NOS II) and enhanced nitric oxide production.
ISSN:0193-1857
1522-1547