Beta2-adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice

No information is yet available as to whether the hepatic beta2-adrenergic receptor (AR) expression level, including beta2-AR-dependent adenylyl cyclase activation, modulates hepatocyte sensitivity to apoptosis in vivo or whether this sensitivity can be modified by beta2-AR ligands. We have examined...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 1999-03, Vol.39 (3), p.G647
Main Authors: Andre, Claudine, Couton, Dominique, Gaston, Jesintha, Erraji, Loubna
Format: Article
Language:English
Subjects:
Cellular biology
Genes
Liver
Online Access:Get full text
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Summary:No information is yet available as to whether the hepatic beta2-adrenergic receptor (AR) expression level, including beta2-AR-dependent adenylyl cyclase activation, modulates hepatocyte sensitivity to apoptosis in vivo or whether this sensitivity can be modified by beta2-AR ligands. We have examined this using C57BL/6 mice, in which hepatic beta2-AR densities are low, and transgenic F28 mice, which overexpress beta2-ARs and have elevated basal liver adenylyl cyclase activity.
ISSN:0193-1857
1522-1547