Estradiol alters cholecystokinin stimulus-response coupling in rat pancreatic acini

We have previously demonstrated that altered exocrine pancreatic stimulus-secretion coupling is associated with ovariectomy and chronic estradiol administration. To elucidate possible mechanisms underlying those effects we examined the ability of chronic administration of different doses of estradio...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 1998-11, Vol.38 (5), p.G993-G998
Main Authors: BLEVINS, G. T, MCCULLOUGH, S. S, WILBERT, T. N, ISOM, R. M, CHOWDHURY, P, MILLER, S. T
Format: Article
Language:English
Subjects:
Biochemistry
Biological and medical sciences
Cellular biology
Exocrine pancreas
Fundamental and applied biological sciences. Psychology
Pancreas
Pharmacology
Rodents
Vertebrates: digestive system
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Summary:We have previously demonstrated that altered exocrine pancreatic stimulus-secretion coupling is associated with ovariectomy and chronic estradiol administration. To elucidate possible mechanisms underlying those effects we examined the ability of chronic administration of different doses of estradiol to regulate the CCK signal transduction pathway in isolated rat pancreatic acini.
ISSN:0193-1857
1522-1547