NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients

To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transplant recipients. Seventy-six tag SNPs were detected in 155 CsA-treated renal recipient...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacogenomics 2017-03, Vol.18 (4), p.381-392
Main Authors: Xu, Qinxia, Qiu, Xiaoyan, Jiao, Zheng, Zhang, Ming, Chen, Jianping, Zhong, Mingkang
Format: Article
Language:English
Subjects:
Adult
Alzheimer's disease
Calcineurin
Cyclosporine - therapeutic use
Cyclosporins
Diabetes
Drug dosages
Female
Follow-Up Studies
Gene expression
Genotype
Genotype & phenotype
Glomerular filtration rate
Graft rejection
Graft Rejection - genetics
Graft Rejection - prevention & control
Humans
Immunosuppressive Agents - therapeutic use
Kidney transplantation
Kidney Transplantation - adverse effects
Kidney Transplantation - trends
Male
Middle Aged
NFATC Transcription Factors - genetics
Patients
Polymorphism, Single Nucleotide - genetics
Proteins
Renal function
Retrospective Studies
Risk factors
Single-Blind Method
Single-nucleotide polymorphism
Studies
Transcription factors
Transplant Recipients
Transplants & implants
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transplant recipients. Seventy-six tag SNPs were detected in 155 CsA-treated renal recipients with at least a 5-year follow-up. The associations of SNPs with acute rejection, nephrotoxicity, pneumonia and estimated glomerular filtration rate post transplant were explored. NFATC1 rs3894049 GC was a risk factor for acute rejection compared with CC carriers (p = 0.0005). NFATC1 rs2280055 TT carriers had a more stable estimated glomerular filtration rate level than CC (p = 0.0004). Detecting NFATC1 polymorphisms could help predict CsA efficacy in renal transplant patients.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2016-0171