Vasodilatory effect and structural-activity relationship of a group of iridoid glucosides from Phlomis likiangensis

As a folk medicine, Phlomis likiangensis is traditionally used in China to activate collaterals and protect cardiovascular system. We hypothesized that the beneficial effects of Phlomis likiangensis may be related to vasodilatation. In the present study, twelve known iridoid glucosides (1−12) were i...

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Bibliographic Details
Published in:Fitoterapia 2019-11, Vol.139, p.104365, Article 104365
Main Authors: Hu, Li-Jiao, Qi, Yan-Yan, Chen, Ke-Jin, Yang, Cui, Wu, Hai-Yan, Li, Gan-Peng
Format: Article
Language:English
Subjects:
Aorta
Blood vessels
Cardiovascular system
Endothelium
Glucosides
Iridoid glucosides
Mechanisms
Nitric oxide
Pharmacodynamics
Phlomis
Phlomis likiangensis
Structure-activity relationship
Vasodilatation
Vasodilation
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Summary:As a folk medicine, Phlomis likiangensis is traditionally used in China to activate collaterals and protect cardiovascular system. We hypothesized that the beneficial effects of Phlomis likiangensis may be related to vasodilatation. In the present study, twelve known iridoid glucosides (1−12) were isolated from Phlomis likiangensis. The vasodilatory effects and the underlying mechanisms of the main components (iridoid glucosides) of Phlomis likiangensis on rat aortic rings were investigated. The result showed that iridoid glucosides significantly increased the vasodilatation in rat aortic rings, which was abolished by removing the endothelium of the vessels or by eliminating the generation of nitric oxide. Finally, the structure-activity relationship of compounds 1–12 was also speculated. Our findings provide the first evidence that the iridoid glucosides of Phlomis likiangensis may be the pharmacodynamic basis for its traditional efficacy. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.104365