Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis

A 74-year-old woman was experiencing rheumatoid arthritis complicated with interstitial pneumonitis (IP), and tacrolimus treatment was started. She presented with dyspnea. Chest X-ray and computed tomography (CT) showed ground-glass opacity and IP. Although tacrolimus was stopped, she died of respir...

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Bibliographic Details
Published in:Modern rheumatology 2008-04, Vol.18 (2), p.208-211
Main Authors: Miwa, Yusuke, Isozaki, Takeo, Wakabayashi, Kuninobu, Odai, Tsuyoshi, Matsunawa, Mizuho, Yajima, Nobuyuki, Negishi, Masao, Ide, Hirotsugu, Kasama, Tsuyoshi, Adachi, Mitsuru, Hisayuki, Tomoyuki, Takemura, Tamiko
Format: Article
Language:English
Subjects:
Aged
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Case Report
Drug therapy
Fatal Outcome
Female
Humans
Immunosuppressive Agents - therapeutic use
Inflammatory diseases
Injuries
Lung - drug effects
Lung - pathology
Lung Diseases, Interstitial - complications
Lung Diseases, Interstitial - drug therapy
Lungs
Medicine
Medicine & Public Health
Orthopedics
Respiratory Insufficiency - chemically induced
Respiratory Insufficiency - pathology
Rheumatoid arthritis
Rheumatology
Side effects
Tacrolimus - adverse effects
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Description
Summary:A 74-year-old woman was experiencing rheumatoid arthritis complicated with interstitial pneumonitis (IP), and tacrolimus treatment was started. She presented with dyspnea. Chest X-ray and computed tomography (CT) showed ground-glass opacity and IP. Although tacrolimus was stopped, she died of respiratory failure. At autopsy, both the upper and lower lung fields showed usual IP and the organizing stage of diffuse alveolar damage. The former is common, but the latter is uncommon, suggesting tacrolimus may cause severe alveolar damage.
ISSN:1439-7595
1439-7609
DOI:10.1007/s10165-008-0034-3