Determining Compression Pressure for Amlodipine Nicotinate Floating Tablet Production

• Published in: Journal of pharmaceutical sciences and research 2019-11, Vol.11 (11), p.3565-3569
• Main Authors: Pchelintcev, SO, Krasnyuk, II, Tenyakova, AA, Salova, VG, Nikolaeva, YV, Solovieva, NL, Chernova, SV, Odintsova, EB, Kozlova, ZM
• Format: Article
• Language: English
• Subjects: Drug dosages; Mathematical models; Pharmaceuticals
• ISSN: 0975-1459

Hekkel's mathematical model was used to determine the optimal pressing pressure of tablet composition, which allows predicting the compressibility by comparing the geometric characteristics of a curve constructed by the Hekkel equation and its angle of inclination. Result and discussion Amlodipine nicotinate is a powder with low flowability, small bulk mass, high residual humidity, with particles differing in shape and size. Since the amount of substance per 1 tablet is small (10 mg per 500 mg tablet), the problem of low flowability can be eliminated by introducing excipients with good flowability in sufficient quantities. The data obtained as a result of the experiment were processed by the linear approximation method (least squares method), as a result of which the equation y = bx + a was transformed as follows: y = (0,0065 ± 0,01114) x + 0,3712 ± 1,1232 Confidence probability - 0.95 Number of measurements - 7 Student's coefficient - t = 2.37 Absolute errors: for a - Aa = ± 1.1232 for b - Ab = ± 0.01114 Correlation coefficient - 0,9042 f(x) = 0,0065x + 0,3712 R2 = 0,9042 According to the data obtained, a graph of the pressure value dependence on the natural logarithm of the porosity of the tablets was plotted (figure 2). According to the analysis of the data obtained, fragmentation prevails in the pressing process, as evidenced by a