Retinal neurodegeneration in systemic lupus erythematosus: layer by layer retinal study using optical coherence tomography

Purpose To find early signs of retinal neurodegeneration by comparing the thickness of peripapillary retinal nerve fiber layer (pRNFL) and of all macular layers between systemic lupus erythematosus (SLE) patients without ophthalmologic manifestations and healthy controls. The effect of disease durat...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2019-12, Vol.97 (S263), p.n/a
Main Authors: Dias‐Santos, Arnaldo, Ferreira, Joana, Pinheiro, Sofia, Cunha, João Paulo, Alves, Marta, Papoila, Ana Luísa, Moraes‐Fontes, Maria Francisca, Proença, Rui
Format: Article
Language:English
Subjects:
Anticoagulants
Antihypertensives
Autoimmune diseases
Cardiovascular diseases
Chronic conditions
Diabetes mellitus
Diabetic retinopathy
Disease control
Health risks
Lupus
Mental disorders
Multiple regression analysis
Neurodegeneration
Optical Coherence Tomography
Photoreceptors
Retina
Retinopathy
Risk factors
Segmentation
Statins
Systemic lupus erythematosus
Thinning
Tomography
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Summary:Purpose To find early signs of retinal neurodegeneration by comparing the thickness of peripapillary retinal nerve fiber layer (pRNFL) and of all macular layers between systemic lupus erythematosus (SLE) patients without ophthalmologic manifestations and healthy controls. The effect of disease duration and systemic comorbidities was also studied. Methods Cross‐sectional study, in which retinal segmentation analysis with spectral domain‐optical coherence tomography (SD‐OCT) was performed. For pRNFL thickness, the global and six peripapillary sectors were determined. Each retinal layer thickness was calculated in the nine early treatment diabetic retinopathy study (ETDRS) subfields. Multiple regression analysis was performed. Results Sixty‐eight eyes of 68 SLE patients and 50 eyes of 50 healthy controls were considered. pRNFL was significantly thinner in the SLE group globally (p = 0.026), in temporal superior (p = 0.007) and temporal (p = 0.037) sectors. Multivariable analysis in the SLE group revealed that chronic medication with antihypertensives, statins and anticoagulants were associated with a thinner pRNFL in some sectors (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2019.5177