IRS 1‐ rs10498210 G/A and CCR 5 ‐59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan

BackgroundThe insulin receptor substrate 1 (IRS1) is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop type 2 diabetes. The polymorphisms in the promoter region of C‐C motif chemokine receptor5 (CCR5) are...

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Bibliographic Details
Published in:Molecular genetics & genomic medicine 2019-05, Vol.7 (5)
Main Authors: Keshavarzi, Fatemeh, Golsheh, Shadi
Format: Article
Language:English
Subjects:
CCR5 protein
Chemokines
Deoxyribonucleic acid
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
DNA
Enzymes
Gene polymorphism
Genes
Genotype & phenotype
Genotypes
Glucose
Hyperglycemia
Insulin
Insulin receptor substrate 1
Insulin resistance
Metabolism
Mutation
Polymorphism
Proteins
Restriction fragment length polymorphism
Signal transduction
Studies
Substrates
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Summary:BackgroundThe insulin receptor substrate 1 (IRS1) is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop type 2 diabetes. The polymorphisms in the promoter region of C‐C motif chemokine receptor5 (CCR5) are also being studied as candidates for susceptibility to develop type 2 diabetes. The aim of the current study was to determine the relationship between IRS1 and CCR5 polymorphisms with type 2 diabetes in the Kurdistan population.MethodsGenomic DNA was isolated from the blood by salt extraction method and the polymorphisms were examined using Restriction Fragment Length Polymorphism (RFLP) method.ResultsThe results of current study indicated that the frequency of AA genotype in type 2 diabetic patients in both CCR5 (OR = 2.9, p = 0.04) and IRS1 (OR = 3.3, p = 0.036) were significantly more than controls.ConclusionAccording to the results of this study, the presence of AA genotype in both CCR5 and IRS1 is associated with type 2 diabetes. There was no significant association between AG or GG genotypes with type 2 diabetes.
ISSN:2324-9269
2324-9269
DOI:10.1002/mgg3.631