Serological response to three alternative series of hepatitis B revaccination (Fendrix, Twinrix, and HBVaxPro-40) in healthy non-responders: a multicentre, open-label, randomised, controlled, superiority trial

Serological non-response can be present after hepatitis B vaccination in healthy adults. We aimed to establish which of three revaccination regimens is most effective at inducing protective immunity Healthy adults (aged 18–80 years) from 16 Dutch centres (13 public health services, two university ho...

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Bibliographic Details
Published in:The Lancet infectious diseases 2020-01, Vol.20 (1), p.92-101
Main Authors: Raven, Stijn F H, Hoebe, Christian J P A, Vossen, Ann C T M, Visser, Leo G, Hautvast, Jeannine L A, Roukens, Anna H E, van Steenbergen, Jim E
Format: Article
Language:English
Subjects:
Adults
Age
Analysis
Antibodies
Antigens
Clinical trials
Health care
Health risk assessment
Hepatitis
Hepatitis A vaccine
Hepatitis B
Hepatitis B vaccine
Herpes zoster
Herpes zoster ophthalmicus
Immunogenicity
Infections
Infectious diseases
Laboratories
Medical records
Missing data
Public health
Randomization
Researchers
Schedules
Vaccination
Vaccines
Viruses
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Summary:Serological non-response can be present after hepatitis B vaccination in healthy adults. We aimed to establish which of three revaccination regimens is most effective at inducing protective immunity Healthy adults (aged 18–80 years) from 16 Dutch centres (13 public health services, two university hospitals, and one travel clinic) were included in this multicentre, parallel group, randomised, controlled, superiority trial. The inclusion criterion was vaccine non-response (hepatitis B surface antibody [anti-HBs] titre
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(19)30417-7