Oregonensins A and B, new meroterpenoids from the culture broth of Ganoderma oregonense and their antioxidant activity

Two new meroterpene derivatives ( 1 and 2 ), together with three known compounds ( 3 – 5 ) were isolated from the culture broth of fungus Ganoderma oregonense . Chemical structures of compounds 1 – 5 were determined using spectroscopic methods. All compounds were tested for 2,2′-azinobis(3-ethylbenz...

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Bibliographic Details
Published in:Journal of antibiotics 2020-02, Vol.73 (2), p.112-115
Main Authors: Kim, Ji-Yul, Woo, E-Eum, Ha, Lee Su, Kim, Young-Hee, Lee, In-Kyoung, Yun, Bong-Sik
Format: Article
Language:English
Subjects:
631/61/320
692/700/459/1748
Antioxidants
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Brief Communication
Free Radical Scavengers - chemistry
Free Radical Scavengers - isolation & purification
Free Radical Scavengers - pharmacology
Ganoderma - chemistry
Inhibitory Concentration 50
Life Sciences
Medicinal Chemistry
Microbiology
Monoterpenes - chemistry
Monoterpenes - isolation & purification
Monoterpenes - pharmacology
Organic Chemistry
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Summary:Two new meroterpene derivatives ( 1 and 2 ), together with three known compounds ( 3 – 5 ) were isolated from the culture broth of fungus Ganoderma oregonense . Chemical structures of compounds 1 – 5 were determined using spectroscopic methods. All compounds were tested for 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging efficacy. Compound 1 exhibited significant antioxidant activities with IC 50 values of 31.2 and 65.4 μM in the ABTS and DPPH radical scavenging activities, respectively.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-019-0248-y