Fibrous dysplasia as a possible false-positive finding in68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer

Positron emission tomography/computed tomography (PET/CT) using68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as...

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Bibliographic Details
Published in:World journal of nuclear medicine 2019-10, Vol.18 (4), p.409-412
Main Authors: Ribeiro, André, Lima, Eduardo, Rocha, Maurìcio
Format: Article
Language:English
Subjects:
Antigens
Cancer metastasis
Cancer research
Chief information officers
Computed tomography
Diagnostic systems
Dysplasia
Emission analysis
Glycoproteins
Medical imaging
Membranes
Metastasis
Morphology
NMR
Nuclear magnetic resonance
Nuclear medicine
Physicians
Positron emission
Positron emission tomography
Prostate cancer
Tomography
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Summary:Positron emission tomography/computed tomography (PET/CT) using68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen.68Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient.
ISSN:1450-1147
1607-3312
DOI:10.4103/wjnm.WJNM_111_18