Radical SAM‐Dependent Adenosylation Involved in Bacteriohopanepolyol Biosynthesis

Summary of main observation and conclusion Bacteriohopanepolyols are a group of triterpenoids that play important roles in regulating bacterial cell membrane function. As an intermediate in bacteriohopanepolyol biosynthesis, adenosylhopane production is related to a putative Fe‐S protein HpnH, but t...

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Bibliographic Details
Published in:Chinese journal of chemistry 2020-01, Vol.38 (1), p.39-42
Main Authors: Zhong, Yuting, Ji, Xinjian, Zhang, Qi
Format: Article
Language:English
Subjects:
Adenosylmethionine
Biosynthesis
Cell membranes
Enzymes
Natural products
Triterpenoids
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Summary:Summary of main observation and conclusion Bacteriohopanepolyols are a group of triterpenoids that play important roles in regulating bacterial cell membrane function. As an intermediate in bacteriohopanepolyol biosynthesis, adenosylhopane production is related to a putative Fe‐S protein HpnH, but the exact role of this enzyme remains unsolved. Here we report characterization of HpnH as a novel radical S‐adenosylmethionine (SAM) superfamily enzyme. In contrast to almost all the members in the superfamily, HpnH does not initiate the reaction by a hydrogen atom ion process. Instead, it catalyzes the adenosylation of hopene via a radical addition reaction to produce adenosylhopane, representing the second example of radical SAM‐dependent adenosylation involved in natural product biosynthesis.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201900399