Ag2WO4 nanoparticles radiolabeled with technetium-99m: a potential new tool for tumor identification and uptake

Silver tungstate nanoparticles have been presenting attractive characteristics that could allow its usage in the biomedical sciences. In this study, Ag 2 WO 4 nanoparticles with an average size of 242 nm were obtained and radiolabeled with technetium-99m with high labeling-yield as well as high stab...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2020, Vol.323 (1), p.51-59
Main Authors: Santos, Carla Júnia, Filho, Francisco Moura, Campos, Fernanda Lapa, Ferreira, Carolina de Aguiar, de Barros, André Luís Branco, Soares, Daniel Crístian Ferreira
Format: Article
Language:English
Subjects:
Biomedical materials
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heavy Ions
In vivo methods and tests
Inorganic Chemistry
Muscles
Nanomaterials
Nanoparticles
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Technetium
Technetium isotopes
Tumors
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Summary:Silver tungstate nanoparticles have been presenting attractive characteristics that could allow its usage in the biomedical sciences. In this study, Ag 2 WO 4 nanoparticles with an average size of 242 nm were obtained and radiolabeled with technetium-99m with high labeling-yield as well as high stability. Biodistribution studies were carried out in healthy and tumor-bearing mice to determine the nanoparticle’s in vivo behavior. The results revealed an important tumor-to-muscle ratio, reaching values above than 1.5, demonstrated the ability of this nanomaterial in accumulating preferentially in tumor tissue. All results together, converge to consider the Ag 2 WO 4 nanoparticles as a potential system against cancer and a potential new radiolabeled probe for tumor identification and uptake.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-019-06955-2