Graphene/chitosan-functionalized iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles are well known for biomedical applications. The particle size, morphology, surface area, and functionalization are the key parameters that affect their bioactivity properties. Inline to this, the superparamagnetic Fe3O4 nanoparticles were prepared via chemi...

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Bibliographic Details
Published in:Journal of materials research 2019-10, Vol.34 (20), p.3389-3399
Main Authors: Bandi, Suresh, Hastak, Vikram, Pavithra, Chokkakula L.P., Kashyap, Sanjay, Singh, Dhananjay Kumar, Luqman, Suaib, Peshwe, Dilip R., Srivastav, Ajeet K.
Format: Article
Language:English
Subjects:
Applied and Technical Physics
Biocompatibility
Biological activity
Biomaterials
Biomedical Materials
Biomedical Materials, Regenerative Medicine and Drug Delivery
Chitosan
Cytotoxicity
Dilution
Drug dosages
Fourier transforms
Graphene
Gravimetric analysis
Heat treating
Hyperthermia
Inorganic Chemistry
Investigations
Iron oxides
Magnetic fields
Materials Engineering
Materials research
Materials Science
Morphology
Nanocomposites
Nanoparticles
Nanotechnology
Organic chemistry
Particle size
Quantum dots
Raman spectroscopy
Regenerative Medicine and Drug Delivery
Spectrum analysis
Toxicity
Transmission electron microscopy
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Summary:Superparamagnetic iron oxide nanoparticles are well known for biomedical applications. The particle size, morphology, surface area, and functionalization are the key parameters that affect their bioactivity properties. Inline to this, the superparamagnetic Fe3O4 nanoparticles were prepared via chemical coprecipitation method with an average particle size of 6 ± 3 nm. The particles were surface-functionalized with chitosan and in-house prepared reduced graphene oxide (rGO) to obtain chitosan-coated Fe3O4 nanoparticles (C-Fe3O4) and rGO-Fe3O4 nanocomposites (G-Fe3O4), respectively. Upon functionalization, the physicochemical properties of the materials were characterized thoroughly using X-ray diffraction, transmission electron microscopy, vibrating sample magnetometer, Raman Spectroscopy, and thermal gravimetric analysis. Furthermore, they have subjected to cytotoxicity assay, agar two-fold broth dilution test, and disc diffusion assay experiments for the determination of cytotoxicity and antibacterial activities. The effect of surface functionalization on their bioactivity was investigated thoroughly. The surface functionalization with chitosan and rGO has enhanced the bioactivity of the Fe3O4 nanoparticles.
ISSN:0884-2914
2044-5326
DOI:10.1557/jmr.2019.267