Effect of continuous environmental enrichment and aerobic exercise on rat plasma and hippocampal brain-derived neurotrophic factor

Objective: Environmental enrichment (EE) or exercise can positively affect memory function through increased long-term potentiation and neurogenesis, which is facilitated by brain-derived neurotrophic factor (BDNF). BDNF promotes blood vessel growth, angiogenesis linked to adult neurogenesis, and ne...

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Published in:Journal of natural science, biology and medicine biology and medicine, 2019-11, Vol.10 (3), p.20-23
Main Authors: Prasetyo, Sri, Yolanda, Sophie, Ivanali, Kesit
Format: Article
Language:English
Subjects:
Aerobics
Angiogenesis
Animal cognition
Brain-derived neurotrophic factor
Enrichment
Enzyme-linked immunosorbent assay
Exercise
Fitness equipment
Hippocampus
Kinases
Long-term potentiation
Memory
Nervous system
Neurogenesis
Physical fitness
Plasma
Proteins
Studies
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Summary:Objective: Environmental enrichment (EE) or exercise can positively affect memory function through increased long-term potentiation and neurogenesis, which is facilitated by brain-derived neurotrophic factor (BDNF). BDNF promotes blood vessel growth, angiogenesis linked to adult neurogenesis, and neuronal survival. Here, we investigated the effects of EE, aerobic exercise, and their combination on plasma and hippocampal BDNF levels. Materials and Methods: Twenty-four 7-month-old adult male Wistar rats weighing 300-400 g were randomly assigned to the following four groups: control (C), aerobic exercise (A), EE, and combined EE and aerobic exercise (EEA). Interventions were given for 8 weeks, and plasma and hippocampal BDNF levels were measured using enzyme-linked immunosorbent assay. Results: A combination of aerobic exercise and continuous EE produced the largest increase in hippocampal and plasma BDNF levels in adult rats. A positive correlation (r = 0.686, P = 0.002, n = 24) was observed between plasma and hippocampal BDNF levels in adult rats. Conclusion: We conclude that a combination of aerobic exercise and continuous EE increases plasma and hippocampal BDNF in adult rats.
ISSN:0976-9668
2229-7707
DOI:10.4103/jnsbm.JNSBM_20_19