Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo

Purpose With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parame...

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Published in:Journal of medical and biological engineering 2020-02, Vol.40 (1), p.24-34
Main Authors: Lo, Yi-Wen, Ke, Chien-Chih, Lee, Jhih-Shain, Chiu, Hsien-Chih, Lu, Cheng-Hsu, Chen, Sih-Yu, Yang, Wen-Chieh, Hu, Ming-Chin, Yang, Bang-Hung, Huang, Wen-Sheng, Liu, Ren-Shyan
Format: Article
Language:English
Subjects:
Algorithms
Biomedical Engineering and Bioengineering
Bone imaging
Bone mineral density
Cell Biology
Computed tomography
Electric potential
Engineering
High resolution
Image acquisition
Image reconstruction
Imaging
In vivo methods and tests
Linearity
Original Article
Ovariectomy
Performance evaluation
Pixels
Radiology
Spatial discrimination
Spatial resolution
Voltage
X ray tubes
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Summary:Purpose With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parameters and protocols. Methods Imaging quality was evaluated by micro-CT HA and wire phantom. The high power output X-ray tube provides tube voltage from 40 to 90 kV with tube current, 10 to 800 μA. The detector with 1536 × 1944 pixels was implemented by three different binning modes (1 × 1, 2 × 2 and 4 × 4). The GPU-based reconstruction was applied with Feldkamp’s algorithm. The maximum reconstruction volume was 1944 × 1944 × 4536 per scan. The phantom images were acquired by four modes with pixel sizes of 44.9, 22.5,15 and 9 μm. In the animal study, ovariectomy mice were imaged followed by analysis of bone mineral density (BMD) and BV/TV ratio (bone volume/total bone volume). Results Linearity (R 2 ) measured in all imaging settings were > 0.9 and was 0.99962 at setting of 0.2 mm Cu filter, 90 kV tube voltage and 556 μA tube current. The spatial resolution as measured by full width half-maximum amplitude (FWHM) was 24 µm in the mode ultra-high resolution. The bone analysis results show the operated cohort has high significant (p 
ISSN:1609-0985
2199-4757
DOI:10.1007/s40846-019-00487-6