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BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells

Blood–brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N -...

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Bibliographic Details
Published in:Journal of natural medicines 2020, Vol.74 (1), p.212-218
Main Authors: Yano, Mamiko, Nakashima, Souichi, Oda, Yoshimi, Nakamura, Seikou, Matsuda, Hisashi
Format: Article
Language:English
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Summary:Blood–brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N -methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine, N -methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and N -methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and N -methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-019-01368-7