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BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells
Blood–brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N -...
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Published in: | Journal of natural medicines 2020, Vol.74 (1), p.212-218 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Blood–brain barrier (BBB)-permeable components in the methanolic extract of
Nelumbo nucifera
flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from
N. nucifera
flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine,
N
-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine,
N
-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and
N
-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and
N
-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability. |
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ISSN: | 1340-3443 1861-0293 |
DOI: | 10.1007/s11418-019-01368-7 |