Ancestry informative DIP loci for dissecting genetic structure and ancestry proportions of Qinghai Tibetan and Tibet Tibetan groups

Tibetans living in the Qing-Tibet plateau show unique genetic features since they are exposed to the high altitude environment. Accordingly, it is necessary for us to analyze genetic components of the Tibetan groups. Here, genetic structure and ancestry proportions of Tibet Tibetan and Qinghai Tibet...

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Bibliographic Details
Published in:Molecular biology reports 2020-02, Vol.47 (2), p.1079-1087
Main Authors: Jin, Xiao-Ye, Shen, Chun-Mei, Chen, Chong, Guo, Yu-Xin, Cui, Wei, Wang, Yi-Jie, Zhang, Wen-Qing, Kong, Ting-Ting, Zhu, Bo-Feng
Format: Article
Language:English
Subjects:
Alleles
Animal Anatomy
Animal Biochemistry
Asian Continental Ancestry Group - genetics
Biomedical and Life Sciences
China
Ethnic Groups - genetics
Forensic science
Gene Frequency
Genetic analysis
Genetic distance
Genetic Loci
Genetic structure
Genetics, Population
Geography
Histology
Humans
INDEL Mutation
Insertion
Life Sciences
Linkage Disequilibrium
Morphology
Original Article
Phylogeny
Polymorphism, Genetic
Population genetics
Tibet
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Summary:Tibetans living in the Qing-Tibet plateau show unique genetic features since they are exposed to the high altitude environment. Accordingly, it is necessary for us to analyze genetic components of the Tibetan groups. Here, genetic structure and ancestry proportions of Tibet Tibetan and Qinghai Tibetan groups are dissected by using a previously published ancestral deletion/insertion polymorphisms (DIPs) panel. Genetic distributions of the analyzed DIPs in both Tibetan groups reveal that some DIPs show relatively balanced frequency distributions with the values ranging from 0.4 to 0.6, implying that these DIPs could be used as individual identification loci for forensic applications in both groups. Besides, the cumulative power of discrimination of the panel also reflects that the panel could serve as a valuable tool for forensic individual identifications in Tibet Tibetan and Qinghai Tibetan groups. Population genetic analyses including principal component analysis, D A genetic distances, phylogenetic tree, and genetic structure reveal that two studied Tibetan groups have closer genetic affiliations with East Asian populations. Genetic differentiation analyses of two Han populations, Xinjiang Uyghur and two Tibetan groups reveal that some DIP loci might be informative for differentiating Uyghurs from the other populations.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-019-05202-x