Recent progress in synthesis and application of mussel-inspired adhesives

The rapid and robust adhesion of marine mussels to diverse solid surfaces in wet environments is mediated by the secreted mussel adhesive proteins which are abundant in a catecholic amino acid, l -3,4-dihydroxyphenylalanine (Dopa). Over the last two decades, enormous efforts have been devoted to the...

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Bibliographic Details
Published in:Nanoscale 2020-01, Vol.12 (3), p.137-1324
Main Authors: Guo, Qi, Chen, Jingsi, Wang, Jilei, Zeng, Hongbo, Yu, Jing
Format: Article
Language:English
Subjects:
Adhesion
Adhesives
Biomedical engineering
Catechol
Crosslinking
Dihydroxyphenylalanine
Hydrogels
Hydrogen bonding
Hydrophobicity
Mechanical properties
Mussels
Organic chemistry
Polyester resins
Proteins
Solid surfaces
Water resistance
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Summary:The rapid and robust adhesion of marine mussels to diverse solid surfaces in wet environments is mediated by the secreted mussel adhesive proteins which are abundant in a catecholic amino acid, l -3,4-dihydroxyphenylalanine (Dopa). Over the last two decades, enormous efforts have been devoted to the development of synthetic mussel-inspired adhesives with water-resistant adhesion and cohesion properties by modifying polymer systems with Dopa and its analogues. In the present review, an overview of the unique features of various mussel foot proteins is provided in combination with an up-to-date understanding of catechol chemistry, which contributes to the strong interfacial binding via balancing a variety of covalent and noncovalent interactions including oxidative cross-linking, electrostatic interaction, metal-catechol coordination, hydrogen bonding, hydrophobic interactions and π-π/cation-π interactions. The recent developments of novel Dopa-containing adhesives with on-demand mechanical properties and other functionalities are then summarized under four broad categories: viscous coacervated adhesives, soft adhesive hydrogels, smart adhesives, and stiff adhesive polyesters, where their emerging applications in engineering, biological and biomedical fields are discussed. Limitations of the developed adhesives are identified and future research perspectives in this field are proposed. This review article gives an overview of the molecular adhesion mechanisms and recent development of mussel inspired functional adhesives.
ISSN:2040-3364
2040-3372
DOI:10.1039/c9nr09780e