Association of MAPK and its regulatory miRNAs (603, 4301, 8485, and 4731) with the malignant transformation of oral lichen planus

Oral lichen planus (OLP) is a potentially malignant oral lesion that may transform into oral squamous cell carcinoma (OSCC). The purpose of this study was to assess the level of expression of MAPK/ERK1/2 gene, and microRNA (miR)-603, 4301, 8485, and 4731 in the MAPK signaling pathway in OLP and OSCC...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2020-02, Vol.47 (2), p.1223-1232
Main Authors: Gholizadeh, Narges, Emami Razavi, Amirnader, Mohammadpour, Hadiseh, Tavakol, Fatemeh, Sheykhbahaei, Nafiseh
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomarkers
Biomedical and Life Sciences
Case-Control Studies
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Gene Expression
Genetic transformation
Histology
Humans
Lichen planus
Lichen Planus, Oral - genetics
Lichen Planus, Oral - metabolism
Lichen Planus, Oral - pathology
Life Sciences
MAP kinase
MicroRNAs
MicroRNAs - genetics
miRNA
Mitogen-Activated Protein Kinases - genetics
Mitogen-Activated Protein Kinases - metabolism
Morphology
Multigene Family
Oral cancer
Oral squamous cell carcinoma
Original Article
Polymerase chain reaction
Prognosis
Reverse transcription
Signal transduction
Squamous cell carcinoma
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oral lichen planus (OLP) is a potentially malignant oral lesion that may transform into oral squamous cell carcinoma (OSCC). The purpose of this study was to assess the level of expression of MAPK/ERK1/2 gene, and microRNA (miR)-603, 4301, 8485, and 4731 in the MAPK signaling pathway in OLP and OSCC lesions. This case–control study evaluated 26 OSCC, 20 OLP and 20 healthy control tissue specimens. After RNA extraction, the respective miRNA and MAPK/ERK1/2 mRNA levels were assessed by quantitative reverse transcription polymerase chain reaction (RT-PCR). Significant upregulation of MAPK/ERK1/2 gene was noted in the OLP and OSCC specimens compared with healthy controls (p 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-019-05223-6