An Approach to Factor Assays in Patients with Strong Lupus Anticoagulants

Higb-titer lupus anticoqgulants (LACs) may present technical and diagnostic dffficulties in the evaluation of patients with specific factor deficiencies or inhibitors. These potent LACS, although infrequently encountered, may be very confusing because they do not generate the characteristic pattern...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 1995-03, Vol.1 (2), p.125-130
Main Authors: Armitage, John, Ashcraft, Joy, Kim, Anne, Kaplan, Harold S.
Format: Article
Language:English
Subjects:
Anticoagulants
Lupus
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Summary:Higb-titer lupus anticoqgulants (LACs) may present technical and diagnostic dffficulties in the evaluation of patients with specific factor deficiencies or inhibitors. These potent LACS, although infrequently encountered, may be very confusing because they do not generate the characteristic pattern of rising factor levels with increasing sample dilutions. In addition, they may prevent assessment of individual factor defects by lowering activities below detectable or evaluable levels (
ISSN:1076-0296
1938-2723
DOI:10.1177/107602969500100204