A Functional Ser413/Ser413 PAI-2 Polymorphism Is Associated With Susceptibility and Damage Index Score in Systemic Lupus Erythematosus

Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser413/Cys413 PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 1...

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Published in:Clinical and applied thrombosis/hemostasis 2009-04, Vol.15 (2), p.233-238
Main Authors: Palafox-Sánchez, Claudia A., Vázquez-Del Mercado, Mónica, Orozco-Barocio, Gerardo, García-De la Torre, Ignacio, Torres-Carrillo, Norma, Torres-Carrillo, Nora M., Illades-Aguiar, Berenice, Muñoz-Valle, José F.
Format: Article
Language:English
Subjects:
Genotype & phenotype
Lupus
Polymorphism
Rheumatoid arthritis
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Summary:Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser413/Cys413 PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser413/Ser413 genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser413 allele was associated with systemic lupus erythematosus (P = .04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser413/Ser413 genotype, developed thrombotic events. The lupus patients identified with Ser 413/Ser413 genotype showed an increased damage (57%), compared with Ser413/Cys413 and Cys413/Cys413 genotypes, with significant difference (P = .03). These findings suggest an association of Ser413/Ser413 genotype with greater damage index score and Ser413 allele with systemic lupus erythematosus. Besides, PAI-2 polymorphism could be related with thrombotic phenomena in systemic lupus erythematosus
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029607308868