Synthesis of new α‐aminophosphonates using nanoscale nickel‐based metal–organic framework as a heterogeneous catalyst and their antibacterial activity

An elegant approach was presented for the synthesis of novel α‐aminophosphonates: a three‐component one‐pot condensation of 3‐(trifluoromethyl)aniline, substituted aromatic aldehydes, and diethyl phosphite using a nickel‐based metal–organic framework (Ni‐MOF). The Ni‐MOF was synthesized using 4,4′‐b...

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Bibliographic Details
Published in:Applied organometallic chemistry 2020-02, Vol.34 (2), p.n/a
Main Authors: Rasal, Sarika A., Dhavan, Pratik P., Jadhav, Bhaskar L., Shimpi, Navinchandra G.
Format: Article
Language:English
Subjects:
Aldehydes
Aniline
antibacterial activity
antioxidant activity
Antioxidants
catalysis
Catalysts
Catalytic activity
Chemical synthesis
Chemistry
Differential thermal analysis
Differential thermogravimetric analysis
Emission analysis
Infrared analysis
Metal-organic frameworks
Metals
metal–organic framework
Nickel
Thermogravimetry
α‐Aminophosphonates
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Summary:An elegant approach was presented for the synthesis of novel α‐aminophosphonates: a three‐component one‐pot condensation of 3‐(trifluoromethyl)aniline, substituted aromatic aldehydes, and diethyl phosphite using a nickel‐based metal–organic framework (Ni‐MOF). The Ni‐MOF was synthesized using 4,4′‐biphenyldicarboxylic acid and further characterized using various techniques such as X‐ray diffraction, Fourier‐transform infrared, thermogravimetry/differential thermal analysis, Brunauer–Emmett–Teller, and field‐emission scanning electron microscopy analyses. Ni‐MOF seems to be an eco‐friendly, an easily recyclable, and heterogeneous catalyst up to the eighth run with minimal reduction in its catalytic activity. The synthesized α‐aminophosphonates were also investigated for antibacterial and antioxidant activities. In few cases, compounds 4a–4x show similar as well as higher antibacterial activity. Among the synthesized α‐aminophosphonates, 4a–4x had more potent antibacterial activity against pathogenic bacteria while compounds 4h, 4m, 4n, 4q, 4u, 4v, and 4w exhibited significant antioxidant activity. Nanoscale Ni‐MOF was used for the synthesis of novel α‐aminophosphonate derivaties. The synthesized novel compounds (4a–4x) exhibited good antibacterial and antioxidant activity.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.5317