Synthesis of Spiro[benzo[h]chromene-4,3′-indoles] and Spiro[benzo[f]chromene-1,3′-indoles]

New spiro heterocycles, spiro[benzo[ h ]chromene-4,3′-indoles] and spiro[benzo[ f ]chromene-1,3′-indoles], have been synthesized in 50–60% yield by three-component condensation of substituted isatins with malononitrile or ethyl cyanoacetate and naphthalen-1-ol or naphthalen-2-ol. The described react...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2019-12, Vol.55 (12), p.1821-1825
Main Authors: Poghosyan, S. H., Poghosyan, M. V.
Format: Article
Language:English
Subjects:
Cascade chemical reactions
Chemistry
Chemistry and Materials Science
Indoles
Malononitrile
Organic Chemistry
Synthesis
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Summary:New spiro heterocycles, spiro[benzo[ h ]chromene-4,3′-indoles] and spiro[benzo[ f ]chromene-1,3′-indoles], have been synthesized in 50–60% yield by three-component condensation of substituted isatins with malononitrile or ethyl cyanoacetate and naphthalen-1-ol or naphthalen-2-ol. The described reactions follow a cascade cyclization pathway and provide a regioselective method of synthesis of the title compounds.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428019120029