High-Quality Optical Ring Resonator-Based Biosensor for Cancer Detection

• Published in: IEEE sensors journal 2020-02, Vol.20 (4), p.1867-1875
• Main Authors: Ali, Liaquat, Mohammed, Mahmood Uddin, Khan, Mahrukh, Yousuf, Abdul Hamid Bin, Chowdhury, Masud H.
• Format: Article
• Language: English
• Subjects: Biomedical optical imaging; biosensor; Biosensors; Blood; Cancer; cancer cell detection; finite difference time domain; Finite difference time domain method; Leukemia; Optical fiber sensors; Optical fibers; optical ring resonator; Optical ring resonators; Photonics; Q factors; Refractivity; Resonators; Selectivity; Sensitivity analysis; Silicon photonic device; Time domain analysis
• ISSN: 1530-437X; 1558-1748
• DOI: 10.1109/JSEN.2019.2950664

A new design of silicon photonics ring resonator based biosensor for the detection of the diseased cell is proposed. The proposed label-free and high-Q ring resonator has the potential to exhibit high sensitivity and selectivity for detecting different cancer cells, such as leukemia, cervical cancer, and breast cancer. The parameters of the ring resonator are optimized to make the biosensor suitable for detecting cancer cells in the pinch of blood with the sensitivity of more than 200 nanometers per Refractive Index Unit (nm/RIU) and quality factor of 1200. Through the finite difference time domain (FDTD) method, it is observed that the resonant wavelength of a ring resonator can be increased by escalating the refractive index of the modal present on the surface of the ring resonator. The simulation and analysis demonstrate that the outline sensitivity and quality factor of the proposed biosensing platform are acceptable for the cancer cell level detection in the blood sample present on the surface of the resonator. The proposed design also shows sufficiently separated resonant peaks for different cancer cells that open the possibility of highly selective label-free cancer cell detection.