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Antidepressant drug use and subdural hematoma risk
Background Selective serotonin reuptake inhibitors (SSRIs) use may be associated with development of subdural hematoma (SDH). Objectives To estimate SDH risk associated with antidepressant use, including when combined with antithrombotics, or nonsteroidal anti‐inflammatory drugs (NSAIDs). Patients/M...
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Published in: | Journal of thrombosis and haemostasis 2020-02, Vol.18 (2), p.318-327 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Selective serotonin reuptake inhibitors (SSRIs) use may be associated with development of subdural hematoma (SDH).
Objectives
To estimate SDH risk associated with antidepressant use, including when combined with antithrombotics, or nonsteroidal anti‐inflammatory drugs (NSAIDs).
Patients/Methods
We performed this case‐control study based on Danish registries. We included 10 885 incident cases of SDH and 435 379 matched general population controls. We calculated odds ratios (95% confidence interval) adjusted for comorbidity, co‐medication, education level, and income (aOR).
Results
We found that current use of SSRIs (aOR1.32 [1.25‐1.38]) and non‐SSRIs (aOR 1.19 [1.13‐1.26]) was associated with a higher SDH risk, compared with non‐use of antidepressants. Risks were higher with short duration of current use (eg, 3 years of current use: 1.04 [0.93‐1.17] for SSRI and 1.12 [0.98‐1.28] for non‐SSRIs). Combined use of antidepressants with either antithrombotics or NSAIDs yielded similar ORs to those observed for single use of antithrombotics or NSAIDs. Stronger associations were observed for antidepressants combined with both vitamin K antagonists (VKAs) and NSAIDs (SSRI, VKA, & NSAID: aOR 5.51 [2.70‐11‐22]; non‐SSRI, VKA, & NSAID: 6.81 [2.37‐19‐60]).
Conclusions
Antidepressant use was associated with higher risk of SDH that seemed largely restricted to first year of treatment. In absolute terms this risk is judged to be small, given the low SDH incidence rate. With one possible exception (triple use of antidepressants, NSAIDs, and VKAs), risk estimates of SDH for combined regimens of antidepressants with antithrombotics or NSAIDs provided little evidence of interactions. |
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ISSN: | 1538-7933 1538-7836 1538-7836 |
DOI: | 10.1111/jth.14658 |