Altered oxidative stress in healthy old subjects

To understand the magnitude of oxidative phenomena during senescence, we evaluated, as antioxidant, the activity of glutathione peroxidase (GSH-Px) in erythrocytes and plasma uric acid (UA) levels together with the malondialdehyde (MDA) levels in plasma, as an index of lipid peroxidation, in 46 appa...

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Bibliographic Details
Published in:Aging (Milan, Italy) Italy), 1997-06, Vol.9 (3), p.221-223
Main Authors: Rondanelli, M, Melzi d'Eril, G V, Anesi, A, Ferrari, E
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - metabolism
Erythrocytes
Erythrocytes - enzymology
Female
Glutathione Peroxidase - blood
Humans
Lipid Peroxidation
Male
Oxidative Stress
Plasma
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Summary:To understand the magnitude of oxidative phenomena during senescence, we evaluated, as antioxidant, the activity of glutathione peroxidase (GSH-Px) in erythrocytes and plasma uric acid (UA) levels together with the malondialdehyde (MDA) levels in plasma, as an index of lipid peroxidation, in 46 apparently healthy elderly subjects (87 +/- 6 years old; mean +/- SD), and 49 young subjects (29 +/- 4 years old). The elderly subjects had lower erythrocyte GSH-Px activity (15.7 +/- 4.8 vs 20.2 +/- 7.0 U/g Hb, p < 0.001; mean +/- SD) and plasma UA levels (192 +/- 46 vs 240 +/- 54 mmol/L, p < 0.001), but higher MDA levels (5.3 +/- 0.8 vs 4.1 +/- 0.8 mmol/L, p < 0.001) than the young subjects. Of additional interest was the finding of a positive correlation between age and erythrocyte GSH-Px activity (r = 0.74, p < 0.001), and a negative correlation between age and plasma MDA levels (r = -0.83, p < 0.001) in the elderly group. Although erythrocyte (GSH-Px activity was significantly less in the elderly than in the young group, the oldest subjects showed the greatest erythrocyte GSH-Px activity and had lower MDA levels.
ISSN:0394-9532
1594-0667
1720-8319
DOI:10.1007/bf03340153