Phylogenetic Diversity of Orientia tsutsugamushi Isolates in Patients with Scrub Typhus in Bengaluru, India

Scrub typhus has re-emerged as an important cause of acute febrile illness in India. There is a dearth of information on strain diversity of Orientia tsutsugamushi from Karnataka, India, hence the present study sought to address this issue. One hundred clinically suspected cases of scrub typhus/rick...

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Bibliographic Details
Published in:Indian journal of medical microbiology 2019-07, Vol.37 (3), p.438-441
Main Authors: Chunchanur, Sneha K., Venugopal, Shwetha J., Ambica, R., Dakshayani, B.
Format: Article
Language:English
Subjects:
Clustering
Deoxyribonucleic acid
DNA
Gandhi, Rajiv
Genetic diversity
Health sciences
Laboratories
Maximum likelihood method
Orientia tsutsugamushi
phylogenetic analysis
Phylogenetics
Phylogeny
Polymerase chain reaction
Rickettsiosis
Scrub typhus
Studies
Typhus
Vaccines
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Summary:Scrub typhus has re-emerged as an important cause of acute febrile illness in India. There is a dearth of information on strain diversity of Orientia tsutsugamushi from Karnataka, India, hence the present study sought to address this issue. One hundred clinically suspected cases of scrub typhus/rickettsiosis (as per the DHR-ICMR guidelines) were included. Nested-polymerase chain reaction (PCR) for 56-kDa gene and phylogenetic analysis was performed. PCR was positive in 22 cases and phylogenetic analysis showed the presence of different strains, with predominance of clustering (57%) with Gilliam-type for the first time in Karnataka. Knowledge of genetic diversity has implications in development of diagnostics and vaccine.
ISSN:0255-0857
1998-3646
DOI:10.4103/ijmm.IJMM_19_267