Sinonasal NUT midline carcinoma: A new histological entity

Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are most commonly seen in the mediastinum and 35% occur in head and neck. It is a highly agg...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of pathology & microbiology 2020-01, Vol.63 (1), p.103-105
Main Authors: Vakani, Pragya, Maheshwari, Jainil, Maheshwari, Mukesh, Shah, Bhoomi
Format: Article
Language:English
Subjects:
Adult
Antibodies
Cancer
Cancer treatment
Carcinoma
Carcinoma - classification
Carcinoma - diagnostic imaging
Carcinoma - pathology
Cell Cycle Proteins - genetics
Chemotherapy
Dizziness
Gene Rearrangement
Genes
Genetic aspects
Head and neck
Headache
Histological Techniques
Humans
Immunohistochemistry
Literature reviews
Male
Mediastinum
Medical prognosis
Neutrophils
Nuclear Proteins - genetics
Oncogene Proteins - genetics
Patients
Proteins
Sinuses
Soft Tissue Neoplasms - diagnostic imaging
Soft Tissue Neoplasms - pathology
Sphenoid Sinus - diagnostic imaging
Sphenoid Sinus - pathology
Tomography, X-Ray Computed
Transcription Factors - genetics
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are most commonly seen in the mediastinum and 35% occur in head and neck. It is a highly aggressive tumor with a median survival of 7 months because of ineffective chemotherapy and undefined treatment. Hence, we must differentiate these tumors from other poorly differentiated tumors. Here, we present a case of NUT midline carcinoma of 44-year male, who presented with headache and dizziness, confirmed by immunohistochemistry of NUT antibody. The aim of this case report is to increase the awareness about this entity in adults with brief review of relevant literature.
ISSN:0377-4929
0974-5130
DOI:10.4103/IJPM.IJPM_373_19