Biochemical profile, eating habits, and telomere length among Brazilian children and adolescents

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2020-03, Vol.71, p.110645, Article 110645
• Main Authors: Todendi, Pâmela Ferreira, Martínez, J. Alfredo, Reuter, Cézane Priscila, Matos, William Latosinski, Franke, Silvia Isabel Rech, Razquin, Cristina, Milagro, Fermín Ignacio, Kahl, Vivian Francília Silva, Fiegenbaum, Marilu, Valim, Andréia Rosane de Moura
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adiposity; Adiposity - genetics; Adolescent; Adolescents; Age; Anthropometry; Antioxidants; Biochemistry; Body mass index; Brazil; Cell division; Child; Children; Children & youth; Cholesterol; Cross-Sectional Studies; Deoxyribonucleic acid; Diet; Diet - adverse effects; Dietary intake; DNA; Eating; Eating behavior; Eating habits; Ethnic Groups - genetics; Ethnicity; Families & family life; Family income; Fatty acids; Feeding Behavior - ethnology; Feeding Behavior - physiology; Female; Food intake; Fruits; Girls; Glucose; Habits; Humans; Hypertension; Lifestyles; Male; Nutrition research; Obesity; Oxidative stress; Parameters; Pediatric Obesity - ethnology; Pediatric Obesity - genetics; Polymerase chain reaction; Statistical analysis; Teenagers; Telomerase; Telomere; Telomere Homeostasis - genetics; Telomeres; Values; Vegetables
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2019.110645

•Shorter telomeres are associated with multiple biochemical stressors and obesity in adults.•The association of biochemical profile and dietary components with telomere length (TL) makes it an important issue in nutritional research.•Biochemical parameters and the intake of antioxidant-rich food are associated with the stability of telomere biology among young Brazilians. Lifestyle, obesity, and eating habits are emerging as determinants for the instability of telomeres. The increase in childhood and adolescent obesity and the association of biochemical profiles and dietary components with telomere length (TL) makes it an important issue in nutritional research. The aim of the present study was to investigate TL and its association with ethnic background, adiposity, clinical and biochemical parameters, and dietary patterns among Brazilian children and adolescents. A cross-sectional study encompassing 981 children and adolescents between 7 and 17 y of age was performed. Dietary intake habits, anthropometry, and clinical data were collected. TL analysis was performed by quantitative polymerase chain reaction. Children presented significantly longer TL than adolescents (P = 0.046). Participants who self-declared as black, mulatto, or brown (P < 0.001) also showed longer TL than those who were white. Regarding biochemical parameters, individuals with altered glucose levels had shorter TL than normoglycemic participants in the total sample (P = 0.014). Such difference remained statistically significant in adolescents (P = 0.019). Participants who reported eating fruits and vegetables regularly had longer TL than those who did not (P < 0.001). The results suggested that both biochemical parameters and the intake of antioxidant-rich food, such as fruits and vegetables, are associated with the stability of telomere biology among young Brazilians.