Biosynthesis, Magnetic and Cytotoxic Studies of Hematite Nanoparticles

Magnetic nanoparticles are special nanoparticles used in the biomedical applications such as magnetic separation, drug delivery and magnetic resonance imaging enhancement. They are non-toxic and have high chemical stability. In the present study, α-Fe 2 O 3 nanoparticles (Hematite) were biosynthesiz...

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Bibliographic Details
Published in:Journal of inorganic and organometallic polymers and materials 2020-03, Vol.30 (3), p.767-774
Main Authors: Miri, Abdolhossein, Khatami, Mehrdad, Sarani, Mina
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Biosynthesis
Chemistry
Chemistry and Materials Science
Colon
Cytotoxicity
Drug delivery systems
Hematite
Inorganic Chemistry
Magnetic resonance imaging
Magnetic separation
Magnetism
Nanoparticles
Organic Chemistry
Polymer Sciences
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Summary:Magnetic nanoparticles are special nanoparticles used in the biomedical applications such as magnetic separation, drug delivery and magnetic resonance imaging enhancement. They are non-toxic and have high chemical stability. In the present study, α-Fe 2 O 3 nanoparticles (Hematite) were biosynthesized using the Salvadora persica aqueous extract. The structures and morphological properties of the synthesized nanoparticles were characterized by PXRD, FESEM, EDX, VSM, Raman and FTIR analysis. The results showed that, the produced nanoparticles are spherical in shape and uniform with particles size about 15–20 nm. The purity of the synthesized nanoparticles was found to be high, such that they were specified well in EDX graph. The saturated magnetism (M s ) of the synthesized α-Fe 2 O 3 nanoparticles was equal to 1.8 emu/g, which is higher than the commercial α-Fe 2 O 3 -NPs. This result showed superparamagnetic properties of the synthesized nanoparticles. Cytotoxic activity of these nanoparticles was applied against colon (HT-29) cancer cell lines. Results showed no cytotoxic activity at concentrations lower than 125 μg/mL. Therefore, it can be concluded that, the synthesized nanoparticles can be used in the biomedical applications.
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-019-01245-6