Facile synthesis of indolizines using layered double hydroxides@poly(p‐phenylenediamine) as a catalyst with a green tool (neat technology)

The three‐component reaction of phenacyl bromide, dimethyl acetylenedicarboxylate and pyridine is catalyzed by layered double hydroxides@poly(p‐phenylenediamine) (LDHs@PpPDA), in a one‐pot reaction, in order to give the corresponding indolizines in excellent yields. One of the commonly used methods...

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Bibliographic Details
Published in:Applied organometallic chemistry 2020-03, Vol.34 (3), p.n/a
Main Authors: Karamshahi, Zahra, Ghorbani‐Vaghei, Ramin
Format: Article
Language:English
Subjects:
1,3‐dipolar cycloaddition
Chemistry
DMAD
Hydroxides
indolizine
Phenylenediamine
polymer
pyrazine
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Summary:The three‐component reaction of phenacyl bromide, dimethyl acetylenedicarboxylate and pyridine is catalyzed by layered double hydroxides@poly(p‐phenylenediamine) (LDHs@PpPDA), in a one‐pot reaction, in order to give the corresponding indolizines in excellent yields. One of the commonly used methods to synthesize indolizines is the three component reaction among phenacyl bromide, dimethyl acetylenedicarboxylate and pyridine. The selection of suitable catalyst for developing of this reaction is a key point in the synthesis of these compounds. The main advantages of this work are easy reaction work‐up, short reaction time, high yield and easy recyclability and reusability of the catalyst.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.5347