IR780-loaded zwitterionic polymeric nanoparticles with acidity-induced agglomeration for enhanced tumor retention

[Display omitted] •The zwitterionic diblock copolymer, mPEG-b-P(MAA-co-HMA), was synthesized.•IR780-loaded PLGA nanoparticles covered with mPEG-b-P(MAA-co-HMA) were developed.•Zwitterionic nanoparticles undergoing surface charge change tended to aggregate.•Enhanced tumor retention of IR780-loaded po...

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Bibliographic Details
Published in:European polymer journal 2020-01, Vol.122, p.109400, Article 109400
Main Authors: Lu, I.-Lin, Liu, Te-I, Lin, Hsiao-Chieh, Chang, Siou-Han, Lo, Chun-Liang, Chiang, Wen-Hsuan, Chiu, Hsin-Cheng
Format: Article
Language:English
Subjects:
Acid-triggered agglomeration
Anticancer properties
Cellular structure
Copolymers
Ethylene glycol
Extracellular matrix
Glycolic acid
Histamine
Imidazole
Methacrylic acid
Nanoparticles
NIR-activated photothermal therapy
Polyethylene glycol
Promoted tumor retention
Protonation
Residues
Surface charge
Switchable surface charges
Tumors
Zwitterionic copolymers
Zwitterions
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Summary:[Display omitted] •The zwitterionic diblock copolymer, mPEG-b-P(MAA-co-HMA), was synthesized.•IR780-loaded PLGA nanoparticles covered with mPEG-b-P(MAA-co-HMA) were developed.•Zwitterionic nanoparticles undergoing surface charge change tended to aggregate.•Enhanced tumor retention of IR780-loaded polymeric nanoparticles was achieved. The tumor-targeted delivery of near infrared (NIR)-triggered photothermal therapy (PTT) by varied nanocarriers has captured substantial attention. In order to boost the antitumor efficacy of PTT by promoting cellular uptake and tumor retention of PTT-carrying nanoparticles, the surface charge-changeable polymeric nanoparticles comprising poly(lactic-co-glycolic acid) (PLGA) cores covered with zwitterionic diblock copolymers, methoxypoly(ethylene glycol)-b-poly(methacrylic acid-co-histamine methacryamide), mPEG-b-P(MAA-co-HMA), were developed as vehicles of IR780. Due to the acid-triggered protonation of imidazole groups, the resulting positively charged HMA residues tend to form electrostatic complexes with negatively charged MAA residues, thus facilitating the embedding of outer PEG segments into the neutral and gel-like surfaces and thus the formation of inter-particle aggregation. Taking advantage of the weak acidity of tumor extracellular matrix, the IR780-loaded nanoparticles undergoing acidity-elicited dramatic structural transformation showed appreciably enhanced cellular uptake by TRAMP-C1 cells and prolonged tumor retention time.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2019.109400