Short Communication - Effects of Dietary Aflatoxin B1 on Physiological Biomarkers with Special Reference to Udder Health of Lactating Goats

ABSTRACT The aim of present study was to determine carcinogenic metabolite aflatoxin M1 (AFM1) in milk and to investigate the effects of low doses of dietary aflatoxin B1 (AFB1) on physiological biomarkers with special reference to udder health and serum parameters of lactating goats. Thirty two lac...

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Bibliographic Details
Published in:Pakistan journal of zoology 2020-02, Vol.52 (1), p.405
Main Authors: Haq, Aman Ullah, Aneela Zameer Durrani, Ijaz, Muhammad, Aqeel Javeed, Shah, Muqadder, Haq, Ikramul
Format: Article
Language:English
Subjects:
Aflatoxin B1
Aflatoxin M1
Aflatoxins
Alanine
Alanine transaminase
Alkaline phosphatase
Animal feeding and feeds
Animals
Aspartate aminotransferase
Backup software
Biological markers
Biomarkers
Carcinogens
Cotton
Dairy cattle
Diet
Enzymes
Experiments
Feeds
Food contamination
Food contamination & poisoning
Fungi
Goats
Health
High performance liquid chromatography
Ingestion
Liquid chromatography
Liver cancer
Low level
Mastitis
Metabolites
Milk
Physiological aspects
Physiological effects
Physiology
Plant metabolites
Plants (Organisms)
Researchers
Seeds
Udder
Variance analysis
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Summary:ABSTRACT The aim of present study was to determine carcinogenic metabolite aflatoxin M1 (AFM1) in milk and to investigate the effects of low doses of dietary aflatoxin B1 (AFB1) on physiological biomarkers with special reference to udder health and serum parameters of lactating goats. Thirty two lactating Beetal goats of 3-4 y age, weighing 40.91±0.285, were randomly selected, and equally divided into four groups. Group A was kept as control while animals of groups B, C, and D were individually fed daily with 30µg, 40µg and 50µg of AFB1, respectively, through naturally contaminated cotton seed cake for a 10 days period. Milk samples were tested for aflatoxin M1 (AFM1) through high performance liquid chromatography (HPLC), somatic cell count (SCC) and total viable count (TVC). Blood samples were analyzed for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels. Aflatoxin M1 (AFM1) was detected in all milk samples of the Group B, C, and D in concentration higher than 0.05 ppb. The AFB1 was excreted in milk as metabolite AFM1 @ 1.35-1.59%. Udder health and milk quality deteriorated as SCC and TVC increased. Levels of serum enzymes AST and ALT increased with ingestion of dietary AFB1. It is concluded that ingestion of very low level of AFB1 by lactating goats results in excretion of carcinogenic metabolite AFM1 in milk beyond the permissible level. Dietary AFB1 has role in sub-clinical mastitis and causes injurious effects on general health status of lactating goats.
ISSN:0030-9923