Individual and simultaneous electroanalytical sensing of epinephrine and lidocaine using an anodically pretreated boron-doped diamond electrode by square-wave voltammetry

• Published in: Diamond and related materials 2020-01, Vol.101, p.107649, Article 107649
• Main Authors: Pınar, Pınar Talay, Yardım, Yavuz, Şentürk, Zühre
• Format: Article
• Language: English
• Subjects: Binary mixtures; Boron; Boron-doped diamond electrode; Determination; Diamonds; Electrodes; Epinephrine; Lidocaine; Oxidation; Pharmaceutical dosage forms; Voltammetry
• ISSN: 0925-9635; 1879-0062
• DOI: 10.1016/j.diamond.2019.107649

In this study, the individual and simultaneous determination of lidocaine (LID) and epinephrine (EP) were examined using an anodically pretreated boron-doped diamond (APT-BDD) electrode. The results of cyclic voltammograms of the binary mixtures of EP and LID were manifested by two irreversible and diffusion-controlled peaks at about +0.91 V (for EP) and +1.67 V (for LID) in Britton-Robinson buffer at pH 2.0. The dependence of oxidation peak potential and current on experimental and instrumental parameters was also investigated at the surface of the APT-BDD electrode. Under the optimal conditions, employing square-wave voltammetric mode, the APT-BDD electrode was used for determination of LID and EP simultaneously in the ranges of 0.1–20.0 μmol L−1 and 1.0–100.0 μmol L−1, with detection limits of 0.03 μmol L−1 and 0.27 μmol L−1, respectively. The proposed approach could be used for their determination individually and selectively (in the case of EP) in pharmaceutical dosage forms with acceptable recoveries. [Display omitted] •An alternative and a novel electroanalytical method for the simultaneous quantification of epinephrine and lidocaine on BDD electrode•Practical applicability in the pharmaceutical forms•Developed procedure have some advantageous, such as simplicity of application, cheapness and rapidity