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PEG-400 assisted Kröhnke synthesis of 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C5-C6 cycles with substituted benzylidene group
A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C 5 -C 6 cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered us...
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Published in: | Synthetic communications 2020-03, Vol.50 (5), p.659-668 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C
5
-C
6
cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered using cross-conjugated dienones as substrates by counter synthesis. |
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ISSN: | 0039-7911 1532-2432 |
DOI: | 10.1080/00397911.2019.1706182 |