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PEG-400 assisted Kröhnke synthesis of 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C5-C6 cycles with substituted benzylidene group

A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C 5 -C 6 cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered us...

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Bibliographic Details
Published in:Synthetic communications 2020-03, Vol.50 (5), p.659-668
Main Authors: Batalin, Sergey, Golikova, Margarita, Khrustaleva, Alexandra, Pchelintseva, Nina
Format: Article
Language:English
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Summary:A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C 5 -C 6 cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered using cross-conjugated dienones as substrates by counter synthesis.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2019.1706182