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In vitro and in vivo inhibitory effects of TLR4 agonist, glucopyranosyl lipid A (GLA), on allergic rhinitis caused by Japanese cedar pollen

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Bibliographic Details
Published in:	Allergy (Copenhagen) 2020-02, Vol.75 (2), p.446-449
Main Authors:	Matsumoto, Koji, Kouzaki, Hideaki, Yamamoto, Sayuri, Kikuoka, Hirotaka, Tojima, Ichiro, Meulen, Jan H., Shimizu, Takeshi
Format:	Article
Language:	English
Subjects:	Allergens - adverse effects Allergic rhinitis Animals Antigens, Plant - adverse effects Antigens, Plant - immunology Cells, Cultured Cryptomeria - chemistry Cryptomeria - immunology Disease Models, Animal Glucosides - pharmacology Glucosides - therapeutic use Humans Immunotherapy - methods Japan - epidemiology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lipid A Lipid A - pharmacology Lipid A - therapeutic use Mice Mice, Inbred BALB C Plant Proteins - adverse effects Plant Proteins - immunology Pollen - adverse effects Pollen - immunology Rhinitis, Allergic, Seasonal - epidemiology Rhinitis, Allergic, Seasonal - etiology Rhinitis, Allergic, Seasonal - therapy TLR4 protein Toll-Like Receptor 4 - agonists Toll-like receptors Treatment Outcome
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