Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications

The molecular recognition of the carboxylatopillar[5]arene on methamphetamine showed interconversion between H 2 :G H:G stoichiometries with dependence on drug concentration. The study simulated conditions of severe metabolic acidosis (pH 7.00) and presented intelligent and promising dynamics for th...

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Bibliographic Details
Published in:New journal of chemistry 2020-02, Vol.44 (7), p.271-274
Main Authors: Silveira, Eduardo V, Wanderlind, Eduardo H, Masson, Andrieli K, Cordeiro, Pâmella S, Nascimento, Vanessa, Affeldt, Ricardo F, Micke, Gustavo A
Format: Article
Language:English
Subjects:
Acidosis
Circulatory system
Methamphetamine
Poisons
Recognition
Stoichiometry
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Summary:The molecular recognition of the carboxylatopillar[5]arene on methamphetamine showed interconversion between H 2 :G H:G stoichiometries with dependence on drug concentration. The study simulated conditions of severe metabolic acidosis (pH 7.00) and presented intelligent and promising dynamics for the removal of overdosed drugs or poisons in the circulatory system. The molecular recognition of the carboxylatopillar[5]arene on methamphetamine showed interconversion between H 2 :G H:G stoichiometries with dependence on drug concentration.
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj06213k