Comparative Safety of Bone Remodeling Agents with a Focus on Osteoporosis Therapies

This article reviews the different treatments currently available for osteoporosis and examines the benefits and adverse events that are associated with each. While emphasizing safety considerations, this review summarizes the following treatments for osteoporosis: calcium supplements, fluoride, hor...

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Bibliographic Details
Published in:Journal of clinical pharmacology 2001-03, Vol.41 (3), p.239-250
Main Authors: Kleerekoper, Michael, Schein, Jeffrey R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Remodeling - drug effects
Bones, joints and connective tissue. Antiinflammatory agents
Calcitonin - therapeutic use
Calcitriol - therapeutic use
Calcium - therapeutic use
Diphosphonates - therapeutic use
Drug Therapy, Combination
Female
Fluorides - therapeutic use
Hormone Replacement Therapy - adverse effects
Humans
Medical sciences
Osteoporosis - drug therapy
Osteoporosis - epidemiology
Pharmacology. Drug treatments
Raloxifene Hydrochloride - therapeutic use
Risk Assessment
Selective Estrogen Receptor Modulators
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Summary:This article reviews the different treatments currently available for osteoporosis and examines the benefits and adverse events that are associated with each. While emphasizing safety considerations, this review summarizes the following treatments for osteoporosis: calcium supplements, fluoride, hormone replacement therapy, raloxifene, bisphosphonates, salmon calcitonin, and calcitriol. Before prescribing any of these agents, the clinician should review the risk/benefit profile of each drug in the context of the individual patient's history, concomitant diseases, concurrent medications, and general physical condition.
ISSN:0091-2700
1552-4604
DOI:10.1177/00912700122010050