A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus

We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host-guest modules. This new type of molecule termed ePIP-HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (15), p.2296-2299
Main Authors: Yu, Zutao, Ai, Mengting, Samanta, Soumen K, Hashiya, Fumitaka, Taniguchi, Junichi, Asamitsu, Sefan, Ikeda, Shuji, Hashiya, Kaori, Bando, Toshikazu, Pandian, Ganesh N, Isaacs, Lyle, Sugiyama, Hiroshi
Format: Article
Language:English
Subjects:
Bridged-Ring Compounds - chemistry
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - genetics
Epigenesis, Genetic - genetics
Epigenetics
Imidazoles - chemistry
Loci
Molecular Structure
Transcription factors
Transcription Factors - chemical synthesis
Transcription Factors - chemistry
Transcription Factors - genetics
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Summary:We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host-guest modules. This new type of molecule termed ePIP-HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to a particular DNA locus. ePIP-HoGu not only mimics the transcription factor operation as pairs but is also capable of recruiting the epigenetic modifiers to a particular DNA locus.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09608f