Structural dynamics of tween-based microemulsions for antimuscarinic drug mirabegron

Microemulsions (μEs)-based drug delivery is known to be superior as well as effective due to customizable and easy management, efficiency and capability, and quick drug absorption over a wide range of targets. Herein, two μE formulations were established comprising of clove oil (as oil phase), water...

Full description

Saved in:
Bibliographic Details
Published in:Colloid and polymer science 2020-03, Vol.298 (3), p.263-271
Main Authors: Nazar, Muhammad Faizan, Mujeed, Ayesha, Siddique, Muhammad Yasir, Zafar, Muddassar, Saleem, Muhammad Atif, Khan, Asad Muhammad, Ashfaq, Muhammad, Sumrra, Sajjad Hussain, Zubair, Muhammad, Zafar, Muhammad Nadeem
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Correlation analysis
Drug delivery systems
Electrical resistivity
Fluorescence
Food Science
Infrared analysis
Interface stability
Microemulsions
Microscopy
Nanotechnology and Microengineering
Optical microscopy
Original Contribution
Phase transitions
Physical Chemistry
Polymer Sciences
Scanning transmission electron microscopy
Soft and Granular Matter
Stability analysis
Storage stability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microemulsions (μEs)-based drug delivery is known to be superior as well as effective due to customizable and easy management, efficiency and capability, and quick drug absorption over a wide range of targets. Herein, two μE formulations were established comprising of clove oil (as oil phase), water (as aqueous phase), Tween-80 (as surfactant), isopropanol, and methanol (as cosurfactant) for formulation A (μE-A) and formulation B (μE-B), respectively, and further used for the encapsulation of an antimuscarinic drug, mirabegron (MBG). Multiple complementary measurements, namely, electrical conductivity ( σ ), viscosity ( η ), and optical microscopy, show the existence of phase transition from W/O to O/W μE via intermediate bicontinuous channels. MBG showed long storage stability as well as good solubility i.e. 3.0 and 2.5 wt% at pH 6.4 in optimum μE-A and μE-B, respectively. Furthermore, no apparent aggregation of MBG was observed, as revealed by scanning transmission electron microscopy and peak correlations of IR analysis, suggesting the stability of MBG inside the formulations. Likewise, fluorescence detection senses the interfacial environment of MBG molecules in the examined formulations that could be vital for understanding the mechanism of controlled drug release. Graphical abstract Structural Dynamics of Tween-Based Microemulsions for Antimuscarinic Drug Mirabegron
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-020-04603-w