Palladium supported on polypyrrole/reduced graphene oxidenanoparticles for simultaneous biosensing application of ascorbic acid, dopamine, anduric acid

In this study, we report a facile and effective production process of palladium nanoparticles supported on polypyrrole/reduced graphene oxide (rGO/Pd@PPy NPs). A novel electrochemical sensor was fabricated by incorporation of the prepared NPs onto glassy carbon electrode (GCE) for the simultaneous d...

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Bibliographic Details
Published in:Scientific reports 2020-01, Vol.10 (1)
Main Authors: Buse, Demirkan, Bozkurt Sait, Cellat Kemal, Arıkan Kubilay, Yılmaz Mustafa, Şavk Aysun, Çalımlı, Mehmet Harbi, Nas, Mehmet Salih, Atalar, Mehmet Nuri, Alma Mehmet Hakkı, Sen, Fatih
Format: Article
Language:English
Subjects:
Ascorbic acid
Biosensors
Detection limits
Dopamine
Electrochemistry
Electrodes
Graphene
Nanoparticles
Oxidation
Palladium
Polypyrroles
Uric acid
Vitamin C
Voltammetry
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Summary:In this study, we report a facile and effective production process of palladium nanoparticles supported on polypyrrole/reduced graphene oxide (rGO/Pd@PPy NPs). A novel electrochemical sensor was fabricated by incorporation of the prepared NPs onto glassy carbon electrode (GCE) for the simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The electrodes modified with rGO/Pd@PPy NPs were well decorated on the GCE and exhibited superior catalytic activity and conductivity for the detection of these molecules with higher current and oxidation peak intensities. Simultaneous detection of these molecules was achieved due to the high selectivity and sensitivity of rGO/Pd@PPy NPs. For each biomolecule, well-separated voltammetric peaks were obtained at the modified electrode in cyclic voltammetry (CV) and differential pulse voltammetry (DPV) measurements. Additionally, the detection of these molecules was performed in blood serum samples with satisfying results. The detection limits and calibration curves for AA, DA, and UA were found to be 4.9 × 10−8, 5.6 × 10−8, 4.7 × 10−8 M (S/N = 3) and ranging from 1 × 10−3 to 1.5 × 10−2 M (in 0.1 M PBS, pH 3.0), respectively. Hereby, the fabricated rGO/Pd@PPy NPs can be used with high reproducibility, selectivity, and catalytic activity for the development of electrochemical applications for the simultaneous detection of these biomolecules.
ISSN:2045-2322
DOI:10.1038/s41598-020-59935-y