Advances and Prospects in Gold‐Catalyzed C−H Activation

• Published in: Asian journal of organic chemistry 2020-02, Vol.9 (2), p.144-161
• Main Authors: Meera, Gopinadh, Rohit, K. R., Treesa, G. S. Susan, Anilkumar, Gopinathan
• Format: Article
• Language: English
• Subjects: Activation; annulation; catalysis; Chemical bonds; Chemical reactions; Chemical synthesis; Coupling (molecular); Cross coupling; C−C coupling; C−H activation; Gold; Heterocyclic compounds; Organic chemistry
• ISSN: 2193-5807; 2193-5815
• DOI: 10.1002/ajoc.202000020

The omnipresent character of C−H bonds in organic molecules gives a wide variety of opportunities for the synthesis of a number of functionalized molecules by the activation of the C−H bonds. One of those methods is gold‐catalyzed C−H activation. Recent developments in the area of gold‐catalyzed C−H activation involves annulation reactions leading to the formation of heterocyclic compounds, Au‐catalyzed cross coupling reactions, and C−H functionalization reactions with high atom efficiency. In this short review we summarize the developments and studies carried out in gold‐catalyzed C−H activation over the past decade. A golden opportunity: C−H bonds in organic molecules are an excellent opportunity for the synthesis of functionalized molecules by activation of these bonds. Recent developments in the area of gold‐catalyzed C−H activation involves annulation reactions leading to heterocyclic compounds, Au‐catalyzed cross coupling reactions, and C−H functionalization reactions with high atom efficiency. In this short review we summarize the developments and studies on gold‐catalyzed C−H activation in the past decade.